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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TUBB1
All Species:
2.73
Human Site:
T439
Identified Species:
4.29
UniProt:
Q9H4B7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.79
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H4B7
NP_110400.1
451
50327
T439
L
E
E
D
E
E
V
T
E
E
A
E
M
E
P
Chimpanzee
Pan troglodytes
Q8WP14
444
49773
E437
A
E
E
E
E
D
E
E
Y
A
E
E
E
V
A
Rhesus Macaque
Macaca mulatta
XP_001082345
451
50234
M439
L
E
E
D
E
E
V
M
E
E
A
E
M
K
P
Dog
Lupus familis
XP_543075
458
50159
V440
E
E
E
D
A
E
A
V
G
E
A
E
M
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERD7
450
50400
Y437
A
E
E
E
G
E
M
Y
E
D
D
D
E
E
S
Rat
Rattus norvegicus
Q6P9T8
445
49782
E437
A
E
E
E
G
E
F
E
E
E
A
E
E
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511352
452
50925
E439
L
E
E
Y
E
E
I
E
G
E
V
E
V
E
R
Chicken
Gallus gallus
P09207
446
50135
E439
V
E
E
Y
E
E
A
E
A
S
P
E
K
E
T
Frog
Xenopus laevis
P13602
443
49705
E435
A
T
A
D
E
Q
G
E
F
E
E
E
E
D
E
Zebra Danio
Brachydanio rerio
XP_686874
466
52560
E441
Y
E
E
E
E
V
M
E
E
E
S
S
I
A
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24560
447
50129
E439
E
D
A
E
F
E
E
E
Q
E
A
E
V
D
E
Honey Bee
Apis mellifera
XP_392313
447
50157
E439
E
D
A
E
F
D
E
E
Q
E
A
E
V
D
E
Nematode Worm
Caenorhab. elegans
P41937
444
49782
D437
A
D
D
E
G
E
F
D
E
H
D
Q
D
V
E
Sea Urchin
Strong. purpuratus
XP_791790
447
50098
D437
A
E
E
E
G
E
F
D
E
E
E
E
D
E
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P18025
446
49944
E437
A
D
E
E
G
E
Y
E
D
E
E
E
G
D
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.6
98.6
81
N.A.
77.8
78
N.A.
87.6
83.5
77.8
76.1
N.A.
78
77.8
76.7
78.2
Protein Similarity:
100
86.9
99.3
91.4
N.A.
89.1
88.2
N.A.
94.2
91.8
88.2
87.7
N.A.
88.9
88.9
88
88.4
P-Site Identity:
100
26.6
86.6
66.6
N.A.
33.3
53.3
N.A.
53.3
40
26.6
33.3
N.A.
26.6
20
13.3
46.6
P-Site Similarity:
100
40
93.3
66.6
N.A.
60
60
N.A.
66.6
46.6
40
60
N.A.
60
60
40
53.3
Percent
Protein Identity:
N.A.
73.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
85.5
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
20
0
7
0
14
0
7
7
40
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
27
7
27
0
14
0
14
7
7
14
7
14
27
0
% D
% Glu:
20
67
74
60
47
74
20
60
47
74
27
80
27
47
27
% E
% Phe:
0
0
0
0
14
0
20
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
34
0
7
0
14
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% K
% Leu:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
14
7
0
0
0
0
20
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
20
% P
% Gln:
0
0
0
0
0
7
0
0
14
0
0
7
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
0
0
0
0
0
0
0
0
7
7
7
0
0
7
% S
% Thr:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
7
% T
% Val:
7
0
0
0
0
7
14
7
0
0
7
0
20
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
14
0
0
7
7
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _